Arianna Vendittelli made her debut in 2010 at the Salzburg Festspiele, singing the role of Carmi in Mozart's Betulia liberata under the baton of Riccardo Muti. For many years, she performed as a zwischenfach soprano, specializing in pants roles (en travesti), particularly within the Baroque repertoire. She subsequently transitioned fully to the mezzo-soprano repertoire, embracing Mozart and bel canto roles to widespread acclaim from both audiences and critics. She has performed at several internationally renowned theaters and festivals, including the Gran Teatre del Liceu in Barcelona, the Teatro di San Carlo in Naples, the Salzburg Festispiele, the Palau de les Arts in Valencia, the Théâtre des Champs-Élysées in Paris, the Baden-Baden Festival, and the Theater an der Wien. Arianna portrayed Giovanna Seymour in Donizetti's Anna Bolena in a new production conducted by Diego Fasolis and directed by Carmelo Rifici in Lugano, Reggio Emilia, Modena, and Piacenza. She has received high praise for her Rossini interpretations, performing at the San Carlo in Naples in the title role of Ermione(conducted by Alessandro De Marchi, directed by Jacopo Spirei) and as Amaltea in Mosè in Egitto(conducted by Stefano Montanari, directed by David Pountney), as well as the role of Matilde in Elisabetta, Regina d'Inghilterra with Jean-Christophe Spinosi. Under the direction of Ottavio Dantone, she performed and recorded the title role in Handel's Serse on tour in Italy, and played Idaspe in Vivaldi's Tamerlano (recorded for the Vivaldi Edition on the Naïve label) at the Theater an der Wien. Also under Dantone's baton, she sang Minerva in Il ritorno di Ulisse in patria in Robert Carsen's award-winning production for the Maggio Musicale Fiorentino, and appeared in a production directed by Pier Luigi Pizzi at the Teatro Alighieri in Ravenna, where she also starred as Dido in Purcell's Dido and Aeneas. Since her debut at the Innsbrucker Festwochen der Alten Musik in the world premiere of Cesti's Le nozze in sogno, conducted by Enrico Onofri, she has been a regular guest at the festival. There, under the direction of Alessandro De Marchi, she performed the title role of Bernardo Pasquini's Idalma and as Vagaus in Vivaldi's Juditha triumphans, earning a nomination for the Österreichischer Musiktheaterpreis. Conducted by Dantone and accompanied by Accademia Bizantina, she performed and recorded the title role in Geminiano Giacomelli's Cesare in Egitto, directed by Leo Muscato. Arianna was also heard as Susanna (Le nozze di Figaro), Donna Elvira (Don Giovanni), and Dorabella (Così fan tutte) in the Da Ponte Trilogy during the 2022/2023 season at the Liceu in Barcelona, the Opéra National de Bordeaux, and the Opéra Royal de Versailles, conducted by Marc Minkowski and directed by Ivan Alexandre. During the 2025/2026 season, Arianna brought to life the role of Agrippina with Stéphane Fuget at the Beaune Festival, and the role of Laodice in A. Scarlatti's Mitridate Eupatore conducted by Giulio Prandi and with award-winning direction by Cecilia Ligorio at the Teatro Massimo in Palermo. She sang Sesto in the successful production of Handel's Giulio Cesare conducted by Marc Minkowski and directed by Vincent Boussard at the Palau de les Arts in Valencia, Nerone in L'incoronazione di Poppea at the Drottningholm Festival conducted by Francesco Corti and Benjamin Lazar, and Minerva at the Salzburg Festival conducted by Gianluca Capuano. She recently reprised the role of Donna Elvira under the direction of Francesco Corti, both for Opera Ballet Vlaanderen and the Palau de la Música in Valencia, and sang Mozart's Mass in C minor at the Teatro Filarmonico in Verona, conducted by Enrico Onofri. In 2020, she recorded a solo album of Vivaldi cantatas for voice and basso continuo with the Abchordis Ensemble, conducted by Andrea Buccarella, for Naïve's prestigious Vivaldi Edition. The album was reviewed and selected for The New York Times' editorial feature "5 Classical Music Albums to Hear Right Now."